Prof Martin Knight

BEng, MSc, PhD

Professor of Mechanobiology

School of Engineering and Materials Science
Queen Mary University of London

+44 (0)20 7882 8868
m.m.knight@qmul.ac.uk
www.sems.qmul.ac.uk/m.m.knight

Research
Publications
Grants

Research

organ-on-a-chip, arthritis, cancer, mechanobiology, cartilage, inflammation

Interests

Martin Knight's research is focussed on 'mechanobiology' or how living cells and tissues respond to physical forces. In particular, he is interested in the mechanical properties of cells and the role of the fascinating cellular structure the primary cilium. Studies from his group were the first to show that primary cilia were required for cartilage mechanotransduction and he has also discovered that cilia are involved in fundamental pathological signalling processes. He is collaborating with Dr Hazel Screen's group to investigate the role of primary cilia associated signalling in tendinopathy. He also has a strong interest in promoting the public understanding of science. Outside work he enjoys the 'great outdoors', exploring wilderness areas with his family. He is interested in wildlife and environmental issues, and has tried his hand at creative ceramics and fly fishing!

Publications

2023

Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM (2023). YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression. vol. 31, (5) 600-612. 10.1016/j.joca.2022.11.001

Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW (2023). Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK. vol. 15, (3) 10.3390/cancers15030635

Meng H, Thompson CL, Coveney CR, Wann AK and Knight MM (2023). Techniques for Visualization and Quantification of Primary Cilia in Chondrocytes. 10.1007/978-1-0716-2839-3_12

2022

Hayward MK, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF and Jones JL (2022). Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion. vol. 8, (1) 10.1038/s41523-022-00464-4

Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P, Knight MM and Gupta HS (2022). Collagen pre-strain discontinuity at the bone—Cartilage interface. vol. 17, (9 September) 10.1371/journal.pone.0273832

Heywood HK, Gardner L, Knight MM and Lee DA (2022). Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems. 1-8. 10.1007/s44164-022-00032-x

2021

Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS (2021). Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage. vol. 136, 314-326. 10.1016/j.actbio.2021.09.037

Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT (2021). A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. vol. 24, (6) 10.1016/j.isci.2021.102676

Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. vol. 24, (6) 10.1016/j.isci.2021.102674

Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype. vol. 13, (12) 10.3390/cancers13122906

Thompson C, Mcfie M, Chapple J, BEALES P and Knight M (2021). Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation. 10.3390/ijms22094313

Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM (2021). Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening. 10.1016/j.bbrc.2021.03.157

Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD (2021). Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models (Front. Bioeng. Biotechnol., (2020), 8, 602646, 10.3389/fbioe.2020.602646). vol. 9, 10.3389/fbioe.2021.658873

Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer., Editors: Balkwill F. 10.1101/2021.02.01.428374

Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson CL and Knight MM (2021). Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1 beta mediated articular cartilage matrix destruction. vol. 29, (1) 89-99. 10.1016/j.joca.2020.08.002

2020

Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD (2020). Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models. vol. 8, 10.3389/fbioe.2020.602646

Fu S, Meng H, Freer F, Kwon J, Shelton JC and Knight MM (2020). Sub-toxic levels of Co²⁺ are anti-inflammatory and protect cartilage from degradation caused by IL-1β. vol. 79, 10.1016/j.clinbiomech.2019.12.006

Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM, Humphreys CJ and Su L (2020). Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films. vol. 14, (9) 11029-11039. 10.1021/acsnano.9b08553

Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P (2020). Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia. vol. 54, (1) 15-26. 10.33594/000000202

2019

Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM and Norris DP (2019). Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model. vol. 10, (1) 10.1038/s41467-019-12067-y

Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS (2019). Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. vol. 97, 437-450. 10.1016/j.actbio.2019.07.055

Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM (2019). Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. vol. 27, (7) 1064-1074. 10.1016/j.joca.2019.03.003

Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K, Thomas G, Knight M, Mirnezami A and Peake N (2019). Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression. 10.3390/cancers11050701

Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A (2019). An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. 10.1016/j.jbiomech.2019.03.024

O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP (2019). Oncometabolite induced primary cilia loss in pheochromocytoma. vol. 26, (1) 165-180. 10.1530/ERC-18-0134

2018

Rowson DT, Shelton JC, Screen HRC and Knight MM (2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. vol. 8, (1) 10.1038/s41598-018-29502-7

Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC (2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. vol. 36, 142-155. 10.22203/eCM.v036a11

Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP and Connelly JT (2018). Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. vol. 131, (10) 215780-215780. 10.1242/jcs.215780

Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC (2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. vol. 72, 434-446. 10.1016/j.actbio.2018.03.054

2017

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. 10.1158/2159-8290.CD-17-0284

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A (2017). Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. vol. 232, (11) 3103-3111. 10.1002/jcp.25761

Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM (2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. vol. 34, 128-141. 10.22203/eCM.v034a09

Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS (2017). The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. 10.1021/acsnano.7b00563

Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H (2017). Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis. vol. 57, 487-497. 10.1016/j.actbio.2017.04.004

THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM (2017). Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria. 10.1002/jcp.25839

2016

Delaine-Smith RM, Burney S, Balkwill FR and Knight MM (2016). Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. vol. 60, 401-415. 10.1016/j.jmbbm.2016.02.019

Sliogeryte K, Botto L, Lee DA and Knight MM (2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. vol. 24, (5) 912-920. 10.1016/j.joca.2015.12.007

Rowson D, Knight MM and Screen HRC (2016). Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon. vol. 34, (12) 2146-2153. 10.1002/jor.23229

Thompson CL, Wiles A, Poole CA and Knight MM (2016). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. vol. 30, (2) 716-726. 10.1096/fj.15-274944

Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM (2016). Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration. vol. 49, (2) 310-317. 10.1016/j.jbiomech.2015.12.034

Knight M, Buchholz N and Bourdoumis A (2016). Physiology of urethral flow. 10.5005/jp/books/12884_30

2015

Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM (2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. vol. 17, (1) 10.1186/s13075-015-0891-z

Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL and Hung CT (2015). Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult. vol. 17, 361-361. 10.1186/s13075-015-0876-y

Thompson CL, Poole CA and Knight MM (2015). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. vol. 100, (4) A39-A40. 10.1096/fj.15-274944

Wang Z, Wann AKT, Thompson CL, Hassen A, Wang W and Knight MM (2015). IFT88 influences chondrocyte actin organization and biomechanics. vol. 24, (3) 544-554. 10.1016/j.joca.2015.10.003

KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A and Poole CA (2015). Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties. 10.1002/jor.22913

Chen J, Bader DL, Lee DA and Knight MM (2015). FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. vol. 15, (5) 10.1142/S0219519415500773

Dalbay MT, Thorpe SD, Connelly JT, Chapple JP and Knight MM (2015). Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1r onto the primary cilium associated with cilia elongation. vol. 33, (6) 1952-1961. 10.1002/stem.1975

Wang Z, Irianto J, Kazun S, Wang W and Knight MM (2015). The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes. vol. 23, (2) 289-299. 10.1016/j.joca.2014.11.003

2014

Rowson D, Knight M and Screen H (2014). 89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix. vol. 48, (Suppl 2) a58-a59. 10.1136/bjsports-2014-094114.88

Wann AKT, Chapple JP and Knight MM (2014). The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity. vol. 26, (8) 1735-1742. 10.1016/j.cellsig.2014.04.004

Irianto J, Lee DA and Knight MM (2014). Quantification of chromatin condensation level by image processing. vol. 36, (3) 412-417. 10.1016/j.medengphy.2013.09.006

Thompson CL, Chapple JP and Knight MM (2014). Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. vol. 22, (3) 490-498. 10.1016/j.joca.2013.12.016

Irianto J, Ramaswamy G, Serra R and Knight MM (2014). Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage. vol. 47, (2) 579-582. 10.1016/j.jbiomech.2013.11.040

Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N and Knight M (2014). In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model. vol. 42, (3) 203-207. 10.1007/s00240-014-0652-5

Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM (2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. vol. 4, 10.1038/srep07307

2013

McMurray RJ, Wann AKT, Thompson CL, Connelly JT and Knight MM (2013). Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. vol. 3, 10.1038/srep03545

Wann AK, Thompson CL, Chapple JP and Knight MM (2013). Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. vol. 2, (1) 10.1186/2046-2530-2-17

Shafat M, Rajakumar K, Syme H, Buchholz N and Knight MM (2013). Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference? vol. 41, (6) 481-486. 10.1007/s00240-013-0608-1

Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA (2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. vol. 104, (4) 759-769. 10.1016/j.bpj.2013.01.006

Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM and Wheeler AP (2013). Super-resolution imaging strategies for cell biologists using a spinning disk microscope. vol. 8, (10) 10.1371/journal.pone.0074604

Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M and Beales PL (2013). Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization. vol. 22, (19) 3858-3868. 10.1093/hmg/ddt241

Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM and Wheeler AP (2013). Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope. vol. 8, (12) 10.1371/annotation/d96769fb-4e7d-4f47-98cf-443447c1471e

Hosny NA, Song M, Knight MM and Wheeler AP (2013). Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope. vol. 24,

2012

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat shock induces rapid resorption of primary cilia. vol. 139, (24) e2408-e2408. 10.1242/dev.091405

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat shock induces rapid resorption of primary cilia. vol. 125, (18) 4297-4305. 10.1242/jcs.100545

Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P and Chapple J (2012). Heat-shock induces rapid resorption of primary cilia. vol. 1, (Suppl 1) 10.1186/2046-2530-1-s1-p52

McMurray R and Knight M (2012). Topographical regulation of primary cilia orientation and length in mesenchymal stem cells. vol. 1, (Suppl 1) 10.1186/2046-2530-1-s1-p34

Wheeler APS, Morad S, Buchholz N and Knight MM (2012). The Shape of the Urine Stream - From Biophysics to Diagnostics. vol. 7, (10) 10.1371/journal.pone.0047133

Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. vol. 103, (6) 1188-1197. 10.1016/j.bpj.2012.07.054

Pravincumar P, Bader DL and Knight MM (2012). Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure. vol. 7, (9) 10.1371/journal.pone.0043938

Wann AKT and Knight MM (2012). Primary cilia elongation in response to interleukin-1 mediates the inflammatory response. vol. 69, (17) 2967-2977. 10.1007/s00018-012-0980-y

Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM (2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: A case study. vol. 11, 72-81. 10.1016/j.jmbbm.2011.06.015

Pravincumar P, Bader D and Knight M (2012). PRESSURE RATE SENSITIVE VISCOELASTIC CELL DEFORMATION INVOLVES ACTIN REMODELLING. vol. 45, 10.1016/s0021-9290(12)70424-4

Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR and Knight MM (2012). Primary cilia mediate mechanotransduction through control of ATP-induced Ca²⁺ signaling in compressed chondrocytes. vol. 26, (4) 1663-1671. 10.1096/fj.11-193649

Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. vol. 11, (3-4) 439-447. 10.1007/s10237-011-0323-1

Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV and Michael-Titus AT (2012). Improved outcome after peripheral nerve injury in mice with increased levels of endogenous Omega-3 polyunsaturated fatty acids. vol. 32, (2) 563-571. 10.1523/JNEUROSCI.3371-11.2012

Hosny NA, Lee DA and Knight MM (2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. vol. 17, (1) 10.1117/1.JBO.17.1.016007

Wann AKT, Thompson C and Knight MM (2012). The role of the primary cilium in chondrocyte response to mechanical loading. 10.1007/978-94-007-5073-9_15

Thompson CL, Chapple JP and Knight MM (2012). Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes. vol. 1, (Suppl 1) P53-P53. 10.1186/2046-2530-1-s1-p53

Wann AKT and Knight MM (2012). A role for IFT88/the primary cilium in the inflammatory response to interleukin-1. vol. 1, (Suppl 1) P60-P60. 10.1186/2046-2530-1-s1-p60

Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M and Beales PL (2012). Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation. vol. 1, (Suppl 1) P88-P88. 10.1186/2046-2530-1-s1-p88

Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR and Knight MM (2012). The primary cilium conducts chondrocyte mechanotransduction. vol. 1, (Suppl 1) P59-P59. 10.1186/2046-2530-1-s1-p59

McMurray R and Knight MM (2012). Topographical regulation of primary cilia orientation and length in mesenchymal stem cells. vol. 1, (Suppl 1) P34-P34.

Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat-shock induces rapid resorption of primary cilia. vol. 1, (Suppl 1) P52-P52.

2011

Gladman S, Lim SN, Dyall S, Knight MM, Priestley JV and Michael-Titus AT (2011). Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation. vol. 18, (6) 317-323. 10.1684/ocl.2011.0421

Gabriel CEL, Nedilko T, Paulose PA, Bach C, Buchholz N and Knight MM (2011). E84 Can Shockwave lithotripsy remove encrustation from ureteric nitinol stents? vol. 10, (7) 10.1016/s1569-9056(11)61205-0

Edirisinghe TY, Knight MM, Buchholz N and Bach C (2011). E70 The influence of extracorporeal shock wave lithotripsy on tissue viability around metallic ureteral stents. vol. 10, (7) 10.1016/s1569-9056(11)61191-3

Shafat M, Nedilko T, Syme H, Buchholz N and Knight MM (2011). E189 Does the composition of feline urine prevent calcium oxalate encrustation of urethral stents? vol. 10, (7) 517-518. 10.1016/s1569-9056(11)61304-3

Nedilko T, Paulose PA, Buchholz N and Knight MM (2011). E75 Comparison of encrustation rates between ureteric metal stents and Double J stents. vol. 10, (7) 10.1016/s1569-9056(11)61196-2

Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. 1-9. 10.1007/s10237-011-0323-1

Lee DA, Knight MM, Campbell JJ and Bader DL (2011). Stem cell mechanobiology. vol. 112, (1) 1-9. 10.1002/jcb.22758

2010

Gladman SJ, Ward RE, Michael-Titus AT, Knight MM and Priestley JV (2010). The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro. vol. 171, (2) 577-587. 10.1016/j.neuroscience.2010.07.009

Vaughan NM, Grainger J, Bader DL and Knight MM (2010). The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures. vol. 48, (12) 1215-1222. 10.1007/s11517-010-0681-3

Wann AKT, Mistry J, Blain EJ, Michael-Titus AT and Knight MM (2010). Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. vol. 12, (6) 10.1186/ar3183

Heywood HK, Knight MM and Lee DA (2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. vol. 223, (3) 630-639. 10.1002/jcp.22061

Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W (2010). A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles. vol. 24, (S1) 975.9-975.9. 10.1096/fasebj.24.1_supplement.975.9

Garcia M and Knight MM (2010). Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway. vol. 28, (4) 510-515. 10.1002/jor.21025

Bader DL and Knight MM (2010). Measuring the biomechanical properties of cartilage cells. 10.1533/9781845697792.1.106

McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S and Poole CA (2010). Mechanical loading modulates chondrocyte primary cilia incidence and length. vol. 34, (5) 441-446. 10.1042/CBI20090094

Archer C, Ralphs J, Säämänen A-M, Arokoski JPA, Jurvelin JS, Kiviranta I, Hinz B, Hunziker EB, Bader DL, Knight MM, Dell’accio F, Vincent TL, Aigner T, Schmitz N, Söder S, McIlwraith CW, Hangody L, Kish G, Koreny T, Hangody LR, Módis L, Brittberg M, Sato M, Andriamanalijaona R, Li H, Elisseeff JH, Trice ME, Benjamin M, Kjær M and Magnusson SP (2010). Contributor contact details. 10.1016/b978-1-84569-417-3.50022-6

Bader DL and Knight MM (2010). 4 Measuring the biomechanical properties of cartilage cells. 10.1533/9781845697792.1.106

Maeda E, Ye S, Knight M, Wang W, Bader D and Lee D (2010). 1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan). vol. 50, (supplement2) 10.2142/biophys.50.s79_4

2009

Knight MM, Mcglashan SR, Garcia M, Jensen CG and Poole CA (2009). Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium? vol. 214, (2) 275-283. 10.1111/j.1469-7580.2008.01021.x

2008

Bader DL and Knight MM (2008). Biomechanical analysis of structural deformation in living cells. vol. 46, (10) 951-963. 10.1007/s11517-008-0381-4

Pingguan-Murphy B and Knight MM (2008). Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes. 10.1007/978-1-4020-6426-5_10

2007

Campbell JJ, Blain EJ, Chowdhury TT and Knight MM (2007). Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. vol. 361, (2) 329-334. 10.1016/j.bbrc.2007.06.185

KNIGHT MM, Chowdhury TT, Campbell JJ and Blain EJ (2007). Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. vol. 361, (21) 329-334. 10.1016/j.bbrc.2007.06.185

Campbell JJ and Knight MM (2007). An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers. vol. 70, (12) 1034-1040. 10.1002/jemt.20513

2006

Chowdhury TT and Knight MM (2006). Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. vol. 209, (3) 845-853. 10.1002/jcp.20768

Pingguan-Murphy B, El-Azzeh M, Bader DL and Knight MM (2006). Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner. vol. 209, (2) 389-397. 10.1002/jcp.20747

Hakimi O, Knight DP, Knight MM, Grahn MF and Vadgama P (2006). Ultrastructure of insect and spider cocoon silks. vol. 7, (10) 2901-2908. 10.1021/bm060528h

Bomzon Z, Knight MM, Bader DL and Kimmel E (2006). Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm. vol. 128, (5) 674-679. 10.1115/1.2246239

Ohashi T, Hagiwara M, Bader DL and Knight MM (2006). Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration. vol. 43, (3-4) 201-214.

Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL (2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. vol. 5, (2-3) 180-191. 10.1007/s10237-006-0020-7

Knight MM, Toyoda T, Lee DA and Bader DL (2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. vol. 39, (8) 1547-1551. 10.1016/j.jbiomech.2005.04.006

Bader DL, Lee DA and Knight MM (2006). Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2). vol. 2005.18, 2-3. 10.1299/jsmebio.2005.18.2

Bomzon Z, Knight MM, Bader DL and Kimmel E (2006). Probing mechanical heterogeneity in chondrocytes using passive microtheology. vol. 39, 10.1016/s0021-9290(06)83854-6

2005

Pingguan-Murphy B, Lee DA, Bader DL and Knight MM (2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. vol. 444, (1) 45-51. 10.1016/j.abb.2005.09.015

2004

Sawae Y, Shelton JC, Bader DL and Knight MM (2004). Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. vol. 32, (6) 860-870. 10.1023/b:abme.0000030261.38396.c0

Lee DA and Knight MM (2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. vol. 100, 307-324. 10.1385/1-59259-810-2:307

Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. vol. 12, (1) 17-24. 10.1016/j.joca.2003.09.001

Lee DA and Knight MM (2004). Mechanical Loading of Chondrocytes Embedded in 3D Constructs. 10.1385/1-59259-810-2:307

2003

Knight MM, Roberts SR, Lee DA and Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. vol. 284, (4) C1083-C1089. 10.1152/ajpcell.00276.2002

Bader DL, SHELTON JC, Knight MM and Sawae Y (2003). Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear. 10.1023/B:ABME.0000030261.38396.c0

2002

Knight MM, Van De Breevaart Bravenboer J, Lee DA, Van Osch GJVM, Weinans H and Bader DL (2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: Temporal changes and calculation of cell modulus. vol. 1570, (1) 1-8. 10.1016/S0304-4165(02)00144-7

2001

Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA (2001). Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. vol. 1526, (2) 141-146. 10.1016/s0304-4165(01)00118-0

Knight MM, Idowu BD, Lee DA and Bader DL (2001). Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. vol. 39, (3) 397-404. 10.1007/BF02345297

Bouten CVC, Knight MM, Lee DA and Bader DL (2001). Compressive deformation and damage of muscle cell subpopulations in a model system. vol. 29, (2) 153-163. 10.1114/1.1349698

Roberts SR, Knight MM, Lee DA and Bader DL (2001). Mechanical compression influences intracellular Ca²⁺ signaling in chondrocytes seeded in agarose constructs. vol. 90, (4) 1385-1391. 10.1152/jappl.2001.90.4.1385

2000

Idowu BD, Knight MM, Bader DL and Lee DA (2000). Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. vol. 32, (3) 165-174. 10.1023/A:1004095207330

Knight DP, KNIGHT MM and Vollrath F (2000). Beta transition and stress-induced phase separation in the spinning of spider dragline silk. vol. 27, (3) 205-210. 10.1016/s0141-8130(00)00124-0

Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL (2000). Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. vol. 33, (1) 81-95. 10.1016/s0021-9290(99)00160-8

1998

Hing K and Knight M (1998). Prize-winning peeks at the microscopic world.

Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL (1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. vol. 16, (6) 726-733. 10.1002/jor.1100160615

Knight MM, Lee DA and Bader DL (1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. vol. 1405, (1-3) 67-77. 10.1016/s0167-4889(98)00102-5

Knight MM, Ghori SA, Lee DA and Bader DL (1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. vol. 20, (9) 684-688. 10.1016/S1350-4533(98)00080-0

Grants

Grants of specific relevance to Tendon Research

Biomedical Research Centre - Organ-on-a-chip and biomaterials infrastructure (Precision Musculoskeletal Care theme)
Knight MM
£435,112 National institute for Health Research (NIHR) (01-12-2022 - 30-12-2027)

MSCA Doctoral Network: Epithelial Exchange Surfaces – From organizing principles to ex vivo disease models
Knight MM
£220,820 EU Commission - Horizon Europe (01-08-2023 - 31-07-2027)

PhD Studentship: Development of a human growth plate organ-chip
Knight MM
£78,000 Queen Mary, University of London (19-09-2022 - 18-09-2025)

PhD Studentship: Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis
Knight MM and Screen H
China Scholarship Council (06-09-2021 - 08-09-2025)

Summary

Human synovium-cartilage organ-chip for personalised surgical screening - Foundation Fellowship (Tim Hopkins)
Knight MM and Hopkins T
£311,203 Versus Arthritis (01-04-2022 - 31-03-2025)

Summary

Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
Knight MM and Cutting BL
Engineering and Physical Sciences Research Council (19-09-2021 - 30-03-2025)

Summary

Development of an Organ-chip Model to examine Muscle Degeneration
Knight MM, Screen H and Fazal MR
Engineering and Physical Sciences Research Council (19-09-2021 - 30-03-2025)

Summary

PhD Studentship: Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
Knight MM and Bishop C
Engineering and Physical Sciences Research Council (06-09-2021 - 03-03-2025)

Summary

Production of a human growth plate organ-chip model of skeletal development
Knight MM and Hopkins T
£199,987 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-02-2023 - 31-01-2024)

Summary

Novel Models of Tendinopathy on a Chip
Screen HRC and Knight MM
ConaCyT (07-10-2019 - 06-01-2024)

Queen Mary+Emulate Organs-on-chips Centre
Screen HRC and Knight MM
£525,375 Emulate Inc and QMUL (20-09-2019 - 19-09-2023)

Summary

MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Screen HRC, Knight MM and El Haj A
£504,557 Medical Research Council (24-08-2020 - 23-08-2023)

Summary

Organ-on-a-chip model of breast cancer bone metastases
Knight MM
£269,601 Cancer Research UK (04-01-2021 - 01-07-2023)

Summary

QM+Emulate Organs-on-Chips Centre Technician
Knight MM
£49,584 Emulate Inc. (05-04-2021 - 01-01-2023)

Summary

PhD Studentship: Investigation of synovium-cartilage pro-inflammatory cross talk and the role of primary cilia using organ-chip models
Screen HRC, Knight MM and Terrazas D
Conacyt Scholarship (16-09-2019 - 15-09-2022)

Drug repurposing for treatment of cilia-related pathologies
Knight MM and Bishop CL
£50,000 Queen Mary Innovations: Proof of Concept Grant (01-04-2021 - 28-02-2022)

Summary

QMUL EPSRC Core Equipment Bid
Wang W, Abrahams I, Knight MM and Parini C
£124,999 Engineering and Physical Sciences Research Council (13-02-2020 - 11-08-2021)

Summary

Organ-on-a-chip Technologies
Screen HRC, Bull AMJ, Haj AJE, Knight MM, Carr AJ, Gunn JPG, Dalby MJ and Workman P
£479,338 Medical Research Council (31-07-2018 - 30-07-2021)

Summary

The mechanics of the collagen fibrillar network in ageing cartilage
Gupta HS and Knight MM
£369,874 Biotechnology and Biological Sciences Research Council (30-09-2017 - 29-09-2020)

Summary

Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions (META-DORM)
Knight MM and Verbruggen S
£137,844 European Research Council (Marie Skodowska-Curie Global Research Fellowship) (01-01-2018 - 30-08-2020)

Summary

Osteoarthritis may be treated as an environmental ciliopathy
Knight MM and Chapple JP
£365,598 Medical Research Council (01-09-2014 - 30-03-2020)

Summary

Mapping mechanotransduction mediated by primary cilia at nanoscale
Knight MM
£89,872 Wellcome Trust (01-03-2016 - 28-02-2018)

Targeting Tissue Stiffness to Treat Colorectal Cancer
Knight MM
£47,720 Bowel and Cancer Research (20-03-2014 - 20-12-2016)

Aberrant chondrocyte primary cilia structure and function drives cartilage degradation in response to IL-1
Knight M
Versus Arthritis (01-09-2012 - 31-08-2015)

Summary

The chondrocyte primary cilium - a purinergic mechanoreceptor?
Knight MM, Jensen CG, Mcglashan SR and Poole CA
£231,845 Wellcome Trust (02-02-2009 - 01-02-2013)

Summary

Platform Grant: Multiscale Mechanobiology for Tissue Engineering
Lee DA, Knight MM and Heywood H
£995,000 Engineering and Physical Sciences Research Council (30-04-2007 - 29-04-2012)